Endocrine Abstracts

Introduction: Thyroid dyshormonogenesis (TD) accounts for 15–20% of congenital hypothyroidism (CH). Levothyroxine is the treatment of choice with the immediate goal to raise the serum T4 as rapidly as possible. Surgical treatment is indicated in case of compressive or suspected goiter.Patients and methods: Seventeen patients with thyroid dyshormonogenesis belonging to 4 Tunisian families were included in a descriptive prospective study. They were fo...

Obesity is considered as an exceeding life style disorder notably in developing countries and it is prevailing at a frightful speed in new world countries as a result of fast food intake, causing raised blood cholesterol levels, which in turn can damage many systems in the body. The present study investigates the hypolipidemic effects of sulphated polysaccharide obtained from Codium fragile (CFSP) in induced obese rats (HFD). The results showed an increase in body weight of HF...

Introduction: Addison disease (AD) is associated with high risk of decreased bone mineral density (BMD) and osteoporosis. Causes are complex, including lifelong glucocorticoid replacement therapy. Several studies have pointed a significant relationship between glucocorticoid dose and low BMD in patients with AD. The aim of our study is to assess the impact of glucocorticoid replacement dose on BMD among Tunisian patients with AD.Patients and Methods: We ...

Objective: to analyze the dietary and metabolic factors predictive of the occurrence of pancreatitis in patients with type 1 diabetes mellitus (T1DM).Patients and Methods: Analytical case-control study of 31 T1DM patients separated into two subgroups: G1 (n=10): T1DM cases with pancreatitis. G2 (n=21): T1DM controls without pancreatitis.Results: The age at diagnosis of T1DM was comparable between the two groups. A...

Objective: To describe the etiological profile the outcomes of acute pancreatitis (AP) in patients with type 1 diabetes (T1DM).Patients and Methods: A retrospective descriptive study of 10 T1DM patients who presented at least one episode of AP during their follow-up.Results: The mean age at diagnosis of T1DM was 19.7±9.3 years, with a female predominance (60%). T1DM was frequently inaugurated by a cardinal syndrome (50%) or spon...

Background and aim: Acromegaly is mostly due to a somatotropic adenoma. Regarding its insidious nature, this adenoma is often revealed at an invasive stage. This study aims to describe the radiological specificities of somatotropic adenomas at the time of diagnosisPatients and methods: We conducted a retrospective study at the Endocrinology department of Hedi Chaker University Hospital, Sfax, Tunisia. We involved 29 patients diagnosed with acromegaly, wh...

Introduction: The simultaneous occurrence in the same patient of more than one endocrinological condition is rare and was described in the multiple endocrine neoplasia (MEN). Here, we report a patient with an unusual combination of primary-hyperparathyroidism, papillary thyroid microcarcinoma, primary-hyperaldosteronism and ACTH-independent Cushing’s syndrome.Case description: A 54-year-old women with a primary-hyperparathyroidism was admitted to ou...

IntroductionUncontrolled hyperglycemia of diabetes is a common cause of renal failure and diabetic nephropathy, which is also called diabetic kidney disease (DKD). Despite improvements in the management of type 1 diabetes (T1D), progression of diabetic nephropathy remains unpredictable and associated with high morbidity and mortality. The objective of this study is to assess the prevalence and risk factors for diabetic kidney disease among adults-onset T...

IntroductionPancreatitis is an inflammatory condition of the pancreas, which has known an increased incidence over the last years. Gallstones and alcohol abuse are the most common causes. But many risk factors are associated with pancreatitis, including Type 2 diabetes who has an estimated risk of pancreatitis at nearly three times the risk of non-diabetics. The aim of our work is to study the relationship between these two entities.<p class="abstext...

Introduction: Distal and symmetrical peripheral polyneuropathy is the most frequent type of diabetic neuropathy. Its painful form (PDN) is the most common cause of non-traumatic neuropathic pain and can place a heavy burden on patients’ lives. Despite the major impact that it can have on the quality of life, PDN is generally underdiagnosed because of a large interindividual variability of symptoms and in the absence of well-established diagnostic criteria.<p class="ab...